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Tomáš Holub was born in Liberec on 19 August 1974. He graduated from the Institute of Economic Studies at the Faculty of Social Sciences, Charles University, where he was awarded a bachelor’s degree in economics (1995), a master’s degree in finance and banking (1997) and a Ph.D. in theoretical economics (2001). In 1997, he received the Bolzano Award, granted by the Rector of Charles University for exceptional research work, for his diploma thesis on Monetary Policy in the Czech Republic (1993–1996). He received the Olga Radzyner Award, granted by the Oesterreichische Nationalbank, and the Award of the Czech Minister of Education, Youth and Sports for outstanding students and graduates in the study programme for his dissertation Three Essays on Central Banking and Credibility. He also undertook study internships at Georgetown University in Washington, D.C. and the London School of Economics and Political Science in London. He worked as a macroeconomist at Komerční banka in 1996–2000. He then joined the CNB, where he held the posts of adviser to the Deputy Governor and adviser to the Governor. He was Executive Director of the Monetary and Statistics Department from 2004 to 30 March 2015 and Executive Director of the Monetary Department from 1 April 2015 to 30 November 2018. He also lectures in monetary economics and international macroeconomics at the Institute of Economic Studies at the Faculty of Social Sciences, Charles University, where he qualified as an associate professor in economic theory in 2011. In the past, he also taught at the University of Economics in Prague. He regularly publishes articles on inflation targeting, exchange rate issues, central bank independence and transparency, central bank finances and price convergence in domestic and foreign economic journals. He is a member of the Czech Economics Society and served as its president in 2006–2007.

Tomáš Holub became a member of the Bank Board of the Czech National Bank on 1 December 2018.